GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs9473555 | 1 | rs1141321 | chr6:49412433 | CENPQ | chr6:49431096-49460820:+ | -0.28 | -5.6 | 4.04E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs1141321 | chr6:49412433 | MUT | chr6:49398994-49431031:- | 0.29 | 5.59 | 4.37E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs7714584 | 1 | rs114244137 | chr5:150264753 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.24 | 1.17E-9 | Crohn's disease |
| BLCA | cis | rs9815354 | 1 | rs114960066 | chr3:41882323 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.93 | 8.2E-21 | Diastolic blood pressure |
| BLCA | cis | rs60843830 | 1 | rs114976176 | chr2:264621 | SH3YL1 | chr2:218138-264810:- | -0.43 | -11.24 | 1.53E-25 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs11532322 | 1 | rs11532322 | chr12:123731423 | ABCB9 | chr12:123413540-123459752:- | -0.3 | -4.26 | 2.62E-5 | Schizophrenia |
| BLCA | cis | rs11532322 | 1 | rs11532322 | chr12:123731423 | OGFOD2 | chr12:123459354-123464588:+ | -0.26 | -4.48 | 9.73E-6 | Schizophrenia |
| BLCA | cis | rs2243480 | 1 | rs11538349 | chr7:65421871 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 4.42 | 1.29E-5 | Diabetic kidney disease |
| BLCA | cis | rs12220238 | 1 | rs115418388 | chr10:75976296 | ADK | chr10:75910965-76469059:+ | 0.31 | 4.7 | 3.66E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs60843830 | 1 | rs11553746 | chr2:272203 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.82 | 1.03E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs12748152 | 1 | rs11555809 | chr1:27216669 | GPN2 | chr1:27205873-27216869:- | 0.46 | 3.91 | 0.000108 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BLCA | cis | rs78153629 | 1 | rs11557072 | chr15:40713374 | C15orf23 | chr15:40674922-40686488:+ | 0.34 | 5.51 | 6.52E-8 | Heschl's gyrus morphology |
| BLCA | cis | rs11799420 | 1 | rs11577745 | chr1:171720909 | VAMP4 | chr1:171669298-171711214:- | 0.3 | 4.05 | 6.16E-5 | Hippocampal atrophy |
| BLCA | cis | rs2275426 | 1 | rs11579634 | chr1:46466391 | CCDC163P | chr1:45960581-45965646:- | 0.35 | 6.63 | 1.16E-10 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs11589562 | chr1:46466721 | CCDC163P | chr1:45960581-45965646:- | 0.29 | 5.4 | 1.19E-7 | Body mass index |